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The body naturally produces some RT3 and this isn't a problem in most people. The
problem arises when the ratio of FT3 to RT3 sinks too low as the RT3 then gets in the way
of the T3 that we need to function causing hypothyroid symptoms.
There are several causes for this ratio getting disturbed, the principal ones that we
know of are:-
- Extreme dieting, the RT3 increases to slow the metabolism and make better use of the
available food
- Low Ferritin
- High cortisol, this disturbs the balance of the thyroid hormones
- Low cortisol, this again disturbs the balance of the thyroid hormones
- Insulin dependent Diabetes
- Low Vitamin B12 levels
In addition to these there are a large list of causes which I have copied
from here
Aging [12]
Burns/thermal injury[63]
Caloric restriction and fasting[64-66]
Chemical exposure[67]
Cold exposure[68]
Chronic alcohol intake[69]
Free radical load[30]
Hemorrhagic shock[70]
Insulin-dependent diabetes mellitus[71]
Liver disease[31]
Kidney disease[72,73]
Severe or systemic illness[74]
Severe injury[76]
Stress[77]
Surgery[15,78-80]
Toxic metal exposure[26-29]
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